Omega-3 Fatty Acids
Omega-3 Fatty Acids
Historically speaking, dietary fats have garnered a bad reputation for being the “black sheep” of all nutrients. They are all too often cast out of our diets due to the belief that they are generally unhealthy and a high source of calories. While the truths of these beliefs may not be entirely misguided, it is important to note that not all fats are created equal. In fact, some dietary fats are actually quite good for you and even necessary for optimal health.[1]
The Discovery of Polyunsaturated Fatty Acids
In an effort to settle the debate as to whether dietary fats are beneficial or even necessary for proper growth and development, George and Mildred Burr (1929) conducted a study looking into the beneficial effects of a fat free diet on a young colony of rats. Their findings were quite shocking and contrary to what most would expect. Although the young rats did lose weight, they were all found to have contracted diseases and later died.[2]
On the up the side, these findings did lead to the discovery of a class of fatty acids (polyunsaturated fatty acids) that were found to be essential for optimal health, yet could not be produced within the body alone. Meaning… we need to include these fats in our diet to sustain normal growth and development.[3]
Essential Polyunsaturated Fatty Acids
There are two classes of essential polyunsaturated fatty acids: Omega-3s and Omega-6s; Omega-5, -7, and -9’s are non-essential.[4]
Omega-6 Fatty Acids
Originating in the seeds of plants, these fatty acids can be found in corn, safflower, soybean, sunflower, and cottonseed oil, as well as in plant-based oils (e.g., evening primrose, blackcurrant seed oil, borage oil, hemp seed oil, oats, barley, spirulina.) and animal-based foods (meat, eggs, dairy products).
Omega-6 has been found to play a key role in:[5]
- Normal growth and development
- Cognitive functioning
- Stimulation of hair growth
- Maintaining bone mass
- Regulating metabolism
- Maintaining the reproductive system
As great as these benefits may seem, these fatty acids can also come at a cost when they are not properly balanced with Omega-3s.[6] In the process of breaking down Omega-6 fatty acids (comprised of linoleic, gamma-linolenic, dihomo-gamma-linolenic, and arachidonic acids), our body produces molecules (eicosanoids, prostaglandin E2, leukotriene), that in excess, can encourage blood clotting, inflammation in the body and suppression of the immune system leaving us more vulnerable to infection.[7]
Omega-3 fatty acids, on the other hand, can help counteract these detrimental effects when properly balanced with Omega-6s. Yet, the average American diet tends to consist of 14 to 25 times more Omega-6s than Omega-3s![8] In fact, research has shown that diets high in Omega-6 fatty acids (low in Omega-3s), has led to increased rates of:
- Cardiovascular diseases[9]
- Inflammatory diseases[10]
- Obesity[11]
- Cancer[12]
- Psychiatric conditions (Depression, Bipolar Disorder, Autism, Alzheimer’s)[13]
Omega-3 Fatty Acids
Though predominately found in fish (in the forms of eicosapentaenoic/EPA & docosahexaenoic/DHA acids; salmon, albacore/blue fin tuna, halibut, trout, sardines, mackerel, and herring), these polyunsaturated fatty acids can also be found in the leaves and seeds of certain plants (in the form of alpha-linolenic acid/ALA; flaxseeds, walnuts, hempseeds, soybeans, some dark green leafy vegetables).[14]
Dating back to the early 1970’s, researchers have found reason to believe that Omega-3 fatty acids serve in warding off the autoimmune response and inflammation in the body,[15] while lowering the risk of chronic diseases (e.g., heart disease, cancer, arthritis, diabetes, hypertension).[16] In addition, Omega-3s enhance blood flow and cognitive/behavioral functioning (e.g., benefitting children with learning disabilities, reducing violence in prison inmates, enhancing mood and preventing neurological disorders).[17]
Omega-3’s Heart Health Benefits:
Ever wonder why North Americans tend to fall victim to higher rates of cardiovascular disease than others around the world? Scientists have found that diets high in Omega 3 fatty acids, such as the Mediterranean diet, can help protect us against stroke and atherosclerosis (hardening of the arteries) triggered by plague buildup and blood clots in the arteries.[18] The Mediterranean diet does not include large amounts of meat, which are high in Omega-6 fatty acids. Rather, this diet promotes foods rich in Omega-3’s, such as whole grains, fresh fruits and veggies, fish, olive oil, garlic, and moderate amounts of red wine.
Research has shown that the two Omega-3 fatty acids found in fish, EPA and DHA, can actually help reduce our chances of developing heart disease by lowering our cholesterol, heart rate, blood pressure and triglycerides.[19] The American Heart Association recommends that healthy adults eat at least 2 servings per week of EPA and DHA-rich foods or take an Omega-3 supplement, like krill oil.[20]
Psychological Benefits of Omega-3 Fatty Acids:
The human brain is rich in polyunsaturated fatty acids, especially DHA (an Omega-3 fatty acid).[21] The concentration of DHA in the brain rises slowly but steadily during fetal development and the first few years of life, proving the importance of Omega-3’s in maintaining proper membrane structure and functioning of the brain. Not only have Omega-3 fatty acids been found to improve cognitive functioning[22] , they have also been found to prevent dementia.[23] More specifically, studies have shown that patients taking Omega-3’s reported improved abilities to mentally respond and learn with fewer errors.[24]Another study conducted by Morris and colleagues found that adults with a higher dietary intake of DHA had a 60 to 70 percent reduction in their risk of developing Alzheimer’s Disease.[25]
If that’s not enough to convince you, Omega-3 deficiencies have been associated with an inability to combat stress appropriately— often leading to adjustment disorders, major depressive disorders, episodes of impulsive violence, and even suicide.[26]
Luckily, studies have suggested that Omega-3 supplements may be used to correct these types of problems. Researchers have found that patients who were given a dose of 2.0 grams per day of Omega-3’s reported reduced stress and depression, and had a decrease in suicidal thinking.[27] Trials involving Omega-3’s have also found that these supplements can reduce symptoms of anxiety.[28]
Meta-analytic studies have also shown that Omega-3’s are in fact more effective than many of the antidepressant medications on the market.[29]
How to Maintain Balance:
Increase your Intake of Omega-3’s!
Research shows that the optimal Omega-6 to Omega-3 ratio should be in the range of 1:1, 1:2, or 1:3.[30] Krill oil has been found to be one of the best sources of Omega-3 fatty acids. It’s phospholipid structure makes it easier for the body to absorb, while holding as much as 50 times the antioxidant power than fish oils.[31]
Take Home Message:
- Not all fats are bad—Polyunsaturated fatty acids are actually considered to be essential for normal growth and development.
- There are two types of Essential Polyunsaturated fatty acids: Omega 3s and Omega 6s— Omega 5, 7, and 9s are non-essential.
- Omega 6 fatty acids are good for us, yet quite damaging to our bodies when in excess.
- Omega 3 fatty acids help counterbalance these detrimental effects that Omega 6s can cause.
- The optimal Omega-6 to Omega-3 ratio should be in the range of 1:1, 1:2, or 1:3—yet, the average American diet tends to consist of 14 to 25 times more Omega-6s than Omega-3s.
- Omega 3s can help maintain a healthy heart, mind and body.
See Also:
- ^ Erasmus, Udo. Fats that heal, fats that kill: the complete guide to fats, oils, cholesterol, and human health. Book Publishing Company, 1993.
- ^ Burr, George O., and Mildred M. Burr. “A new deficiency disease produced by the rigid exclusion of fat from the diet.” Journal of Biological Chemistry 82.2 (1929): 345-367.
- ^ Simopoulos, Artemis P. “Essential fatty acids in health and chronic disease.” The American journal of clinical nutrition 70.3 (1999): 560s-569s.
- ^ Watkins, S. M., et al. “Omega fatty acids.” Food lipids: chemistry, nutrition, and biotechnology. (1998): 463-493.
- ^ Simopoulos, Artemis P., Alexander Leaf, and Norman Salem Jr. “Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids.” Annals of Nutrition and Metabolism 43.2 (1999): 127-130.
- ^ Simopoulos, Artemis P. “The importance of the ratio of omega-6/omega-3 essential fatty acids.” Biomedicine & pharmacotherapy 56.8 (2002): 365-379.
- ^ Harris, William S., et al. “Omega-6 fatty acids and risk for cardiovascular disease a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention.” Circulation 119.6 (2009): 902-907.
- ^ Simopoulos, Artemis P. “The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.” Experimental biology and medicine 233.6 (2008): 674-688.
- ^ Russo, Gian Luigi. “Dietary n− 6 and n− 3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.” Biochemical pharmacology 77.6 (2009): 937-946.
- ^ Simopoulos, Artemis P. “Omega-6/omega-3 essential fatty acid ratio and chronic diseases.” Food Reviews International 20.1 (2004): 77-90.
- ^ Muhlhausler, Beverly S., and Gérard P. Ailhaud. “Omega-6 polyunsaturated fatty acids and the early origins of obesity.” Current Opinion in Endocrinology, Diabetes and Obesity 20.1 (2013): 56-61.
- ^ Yam, Daniel, Abraham Eliraz, and Elliot M. Berry. “Diet and disease–the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid diet.” Israel journal of medical sciences 32.11 (1996): 1134-1143.
- ^ Peet, Malcolm, and Caroline Stokes. “Omega-3 fatty acids in the treatment of psychiatric disorders.” Drugs 65.8 (2005): 1051-1059.
- ^ Wikipedia contributors. “Omega-3 fatty acid.” Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, 13 Aug. 2016. Web. 18 Aug. 2016.
- ^ Wall, Rebecca, et al. “Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids.” Nutrition reviews 68.5 (2010): 280-289.
- ^ Simopoulos, Artemis P. “Essential fatty acids in health and chronic disease.” The American journal of clinical nutrition 70.3 (1999): 560s-569s.
- ^ Chalon, Sylvie. “Omega-3 fatty acids and monoamine neurotransmission.” Prostaglandins, Leukotrienes and Essential Fatty Acids 75.4 (2006): 259-269.
- ^ Kris-Etherton, Penny M., et al. “Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease.” circulation 106.21 (2002): 2747-2757.
- ^ Bucher, Heiner C., et al. “N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials.” The American journal of medicine 112.4 (2002): 298-304.
- ^ Kris-Etherton, Penny M., et al. “Omega-3 fatty acids and cardiovascular disease new recommendations from the American Heart Association.” Arteriosclerosis, thrombosis, and vascular biology 23.2 (2003): 151-152.
- ^ Singh, Meharban. “Essential fatty acids, DHA and human brain.” The Indian Journal of Pediatrics 72.3 (2005): 239-242.
- ^ Kidd, Parris M. “Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids.” Alternative medicine review 12.3 (2007): 207.
- ^ Sydenham, Emma, Alan D. Dangour, and Wee-Shiong Lim. “Omega 3 fatty acid for the prevention of cognitive decline and dementia.” Sao Paulo Medical Journal 130.6 (2012): 419-419.
- ^ Issa, Amalia M., et al. “The efficacy of omega–3 fatty acids on cognitive function in aging and dementia: a systematic review.” Dementia and geriatric cognitive disorders 21.2 (2006): 88-96.
- ^ Morris, Martha Clare, et al. “Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.” Archives of neurology 60.7 (2003): 940-946.
- ^ Hibbeln, Joseph R. “Depression, Suicide and Deficiencies of Omega–3 Essential Fatty Acids in Modern Diets.” Omega-3 Fatty Acids, the Brain and Retina. Vol. 99. Karger Publishers, 2009. 17-30.
- ^ Hallahan, Brian, et al. “Omega-3 fatty acid supplementation in patients with recurrent self-harm.” The British Journal of Psychiatry 190.2 (2007): 118-122.
- ^ Ross, Brian M. “Omega-3 polyunsaturated fatty acids and anxiety disorders.” Prostaglandins, Leukotrienes and Essential Fatty Acids 81.5 (2009): 309-312.
- ^ Freeman, Marlene P., et al. “Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry.” Journal of Clinical Psychiatry67.12 (2006): 1954-1967.
- ^ Simopoulos, Artemis P. “The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.” Experimental biology and medicine 233.6 (2008): 674-688.
- ^ Deutsch, Luisa. “Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms.” Journal of the American college of nutrition 26.1 (2007): 39-48.